Clinically Researched Nutrients to Support Health

CHK Nutrition’s amino acid formulas are based on clinical research that focuses on brain, gut and overall health. This research has examined the clinical and scientific applications of amino acid supplementation in terms of health benefits, impact on wellness and quality of life. This research represents our unwavering commitment to safety, reliability and effectiveness, which sets us apart from many natural approaches.

Based upon research conducted, it is clear that one of the most important areas of brain health is the balanced administration of amino acid nutrients. Most companies have ignored or failed to understand the importance of balanced amino acid supplementation. Without this knowledge, it is possible to do more harm than good when using amino acid supplements.

The Basics of Amino Acid Support

CHK Nutrition’s amino acid formulas support the following neurotransmitters:*

  • Serotonin – known to control mood, appetite, sleep, memory, learning, and temperature regulation.
  • Dopamine, norepinephrine and epinephrine (the catecholamines) – known to control movement,
    balance, motivation, and the drive for reward.

Serotonin and the catecholamines are essential to brain health. However, neither serotonin nor any of the catecholamines can be directly administered to support normal brain health. This is due to a protective layer around the brain known as the blood brain barrier. Serotonin and the catecholamines are not able to cross this protective boundary.

Thankfully, serotonin and the catecholamines can be supported by specific amino acids, which can cross the brain’s protective layer and promote the formation of these neurotransmitters.

*CHK Nutrition’s amino acid products are not drugs. They are not intended to diagnose, treat, cure, mitigate or prevent any disease.

5-HTP is the most direct way to support serotonin.

  • 5-HTP crosses the brain’s protective layer.
  • 5-HTP supports serotonin formation without biochemical feedback inhibition.

Note: Some companies recommend the use of tryptophan to support the formation of serotonin. This approach fails to consider that the conversion of tryptophan into 5-HTP is limited. Once the enzyme converting tryptophan into 5-HTP has reached its threshold, additional tryptophan will not yield additional 5- HTP. Therefore, tryptophan does not support increased serotonin levels as well as 5-HTP.

There are only trace amounts of 5-HTP found in food. Therefore, 5-HTP supplementation is the most direct way of adding additional serotonin support.

L-tyrosine can be used alone to support the catecholamine system or L-tyrosine and Mucuna 40% (a natural source of L-dopa) can work together to support the catecholamine system.

  • L-tyrosine and the L-dopa found in Mucuna 40% cross the brain’s protective layer.
  • L-tyrosine has the unique ability to evenly maintain normal L-dopa levels.
  • L-dopa, which is found in in CHK Nutrition’s Mucuna 40%, is converted directly into dopamine, making it a great way to support health catecholamines levels.

Important: L-tyrosine’s ability to maintain normal L-dopa levels is essential for consistent catecholamine levels. Until recently, L-tyrosine’s importance was not well understood, making it an often overlooked nutrient for supporting catecholamine health. The major consideration when using Mucuna 40% is ensuring that adequate levels of L-tyrosine are present.

Why Balanced Amino Acid Supplementation is Essential

Balanced amino acid precursor administration is necessary because the enzyme that converts L-dopa into dopamine is the same enzyme that converts 5-HTP into serotonin.

The proper ratio and chemistry of balanced administration is more complex than can be covered here. However, a simple explanation is that administering too many precursor molecules of “one side” will reduce the access that “the other side” has to the shared enzyme. Eventually, the outnumbered group will become depleted throughout the body due to its lack of access to the shared enzyme.

For example, if 5-HTP is administered at a higher ratio than recommended, this will reduce the access that L-dopa has to the shared enzyme.  L-dopa will not be able to convert into dopamine in a normal manner. The same is true if you administer L-tyrosine or L-dopa at a higher ratio than recommended, it will crowd out 5-HTP conversion into serotonin. Eventually, the reduced conversion will cause the outnumbered group to be depleted. This depletion will have implications throughout the body. This depletion can occur from the administration of only serotonin precursors, only dopamine precursors, or an incorrectly balanced ratio of both serotonin and dopamine precursors.

Therefore, balanced amino acid supplementation is essential because it is possible to do more harm than good by administering incorrectly balanced amino acid precursors.


Peer-reviewed scientific studies testing CHK Nutrition’s amino acid formulas can be found in the following journals, as well as on PubMed and Dove Press websites:

  1. Neuropsychiatric Disease and Treatment” (Multiple Studies)
  2. “Book: Food and Nutrients in Disease Management”
  3. “Open Access Journal of Urology”(Multiple Studies)
  4. “Neuropsychiatric Disease and Treatment” (Multiple Studies)
  5. “Clinical and Experimental Gastroenterology”
  6. “International Journal of General Medicine” (Multiple Studies)
  7. “International Journal of Nephrology and Renovascular Disease”
  8. “Healthcare and Patient Safety”(Multiple Studies)
  9. “Clinical Pharmacology: Advances and Applications” (Multiple Studies)

Please note: These studies are intended to support structure-functions claims made regarding CHK Nutrition’s products. The studies may involve findings that discuss uses that go outside CHK Nutrition’s product labeling and product structure-function claims. This information is NOT presented to make drug claims about CHK Nutrition’s products. The intent of providing this information is to disseminate the scientific literature currently available about the CHK Nutrition products and the structure-function claims that we offer. Please read these studies to understand the strengths and limitations of the data.

Important: These statements have not been evaluated by the Food and Drug Administration (FDA). These products are not intended to diagnose, treat, cure, mitigate, or prevent any disease.